Limb deficiency with or without Möbius sequence in seven Brazilian children associated with misoprostol use in the first trimester of pregnancy.

@article{Gonzalez1993LimbDW,
  title={Limb deficiency with or without M{\"o}bius sequence in seven Brazilian children associated with misoprostol use in the first trimester of pregnancy.},
  author={Claudette Hajaj Gonzalez and Fernando Regla Vargas and Ana Beatriz P{\'e}rez and Chong A E Kim and D{\'e}cio Brunoni and Maria Joaquina Marques-Dias and C R Leone and J Correa Neto and J C Llerena J{\'u}nior and Jos{\'e} Miguel Caldas de Almeida},
  journal={American journal of medical genetics},
  year={1993},
  volume={47 1},
  pages={59-64}
}
Misoprostol, a synthetic analog of prostaglandin, has been widely used in Brazil as an abortifacient. Abortion is illegal in Brazil. An uncertain number of these abortion attempts are unsuccessful and the pregnancy continues. We report on 7 patients whose mothers attempted to abort using this drug in the first trimester of gestation without success. The 7 patients presented with limb defects and in 4 of them a diagnosis of Möbius sequence was made. 

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