Limb blood flow during exercise is dependent on nitric oxide.

  title={Limb blood flow during exercise is dependent on nitric oxide.},
  author={Andrew J. Maxwell and Eric Schauble and D. Bernstein and John P Cooke},
  volume={98 4},
BACKGROUND We have recently reported that hypercholesterolemia reduces aerobic exercise capacity in mice and that this is associated with a reduced endothelium-dependent vasodilator function, endothelium-derived nitric oxide (EDNO) production, and urinary nitrate excretion. These findings led us to test the hypothesis that EDNO production contributes significantly to limb blood flow during exercise and to determine whether loss of EDNO production is responsible for the decline in exercise… CONTINUE READING


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Hypercholesterolemia impairs exercise capacity: role of nitric oxide

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