Likelihood vs. Information in Aligning Biopolymer Sequences

  title={Likelihood vs. Information in Aligning Biopolymer Sequences},
  author={Timothy L. Bailey},
Biopolymer sequences often contain regions of similarity with other sequences due to homology or common function. A common method of discovering patterns in biopolymer sequences is to align a set of sequences so that certain columns of the alignment have highly non-random residue frequency distributions. The pattern can then be described in terms of a consensus pattern, motif, proole, speci-city matrix or regular expression. This research note shows that a commonly used method of measuring the… CONTINUE READING


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