Ligustrazine corrects Th1/Th2 and Treg/Th17 imbalance in a mouse asthma model.

  title={Ligustrazine corrects Th1/Th2 and Treg/Th17 imbalance in a mouse asthma model.},
  author={Ning-fei Ji and Yu-chun Xie and Ming-shun Zhang and Xin Zhao and Hongyan Cheng and Hong Wang and Kai-sheng Yin and Mao Huang},
  journal={International immunopharmacology},
  volume={21 1},
Asthma is an inflammatory disease closely associated with activated T cells in the lung. Imbalances in Th1/Th2 and Treg/Th17 have been found in asthmatic patients. Ligustrazine from the Chinese herb chuanxiong has been used in China in combination with glucocorticoids to treat asthma. Previous studies have proved that ligustrazine can modulate the expression of transcription factors for Th1 (T-bet) and Th2 (Gata-3) in asthma. In the present study, ligustrazine alleviated allergic airway… CONTINUE READING
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