Lignans 7-hydroxymatairesinol and 7-hydroxymatairesinol 2 exhibit anti-inflammatory activity in human aortic endothelial cells.

@article{Spilioti2014Lignans7A,
  title={Lignans 7-hydroxymatairesinol and 7-hydroxymatairesinol 2 exhibit anti-inflammatory activity in human aortic endothelial cells.},
  author={Eliana Spilioti and Bjarne R. Holmbom and Athanasios G. Papavassiliou and Paraskevi C Moutsatsou},
  journal={Molecular nutrition & food research},
  year={2014},
  volume={58 4},
  pages={749-59}
}
SCOPE In the present study, we evaluated the anti-inflammatory properties of several plant lignans most commonly distributed in foods. 7-Hydroxymatairesinol (HMR) and its major isomer 7-hydroxymatairesinol 2 (HMR2), lariciresinol, secoisolariciresinol, and pinoresinol, isolated from Norway spruce knots were examined. METHODS AND RESULTS We investigated the anti-inflammatory effects of lignans on tumor necrosis factor-α-treated human aortic endothelial cells by measuring the expression of… CONTINUE READING