Lighting up developmental mechanisms: how fluorescence imaging heralded a new era.

@article{Mavrakis2010LightingUD,
  title={Lighting up developmental mechanisms: how fluorescence imaging heralded a new era.},
  author={Manos Mavrakis and Olivier Pourqui{\'e} and Thomas Lecuit},
  journal={Development},
  year={2010},
  volume={137 3},
  pages={373-87}
}
Embryology and genetics have given rise to a mechanistic framework that explains the architecture of a developing organism. Until recently, however, such studies suffered from a lack of quantification and real-time visualization at the subcellular level, limiting their ability to monitor the dynamics of developmental processes. Live imaging using fluorescent proteins has overcome these limitations, uncovering unprecedented insights that call many established models into question. We review how… CONTINUE READING

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