Light-stimulated protein movement in rod photoreceptor cells of the rat retina.

  title={Light-stimulated protein movement in rod photoreceptor cells of the rat retina.},
  author={Nancy J. Philp and Wen-Chang Chang and Kamariah Long},
  journal={FEBS letters},
  volume={225 1-2},
We examined the intracellular distribution of three proteins involved in the cyclic GMP cascade of visual transduction; cGMP phosphodiesterase, the alpha-subunit of G-protein and arrestin. In adult rats, light-induced changes in the amounts of G and arrestin in the photoreceptor cell outer segments were observed both by polyacrylamide gel analysis of purified ROS and by immunocytochemical localization on retinal sections. In dark conditions, G was concentrated in the outer segments of… CONTINUE READING

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