Light microscopic, immunohistochemical, and ultrastructural alterations in patients with melasma.

@article{Grimes2005LightMI,
  title={Light microscopic, immunohistochemical, and ultrastructural alterations in patients with melasma.},
  author={Pearl E. Grimes and Nanaka Yamada and Jag Bhawan},
  journal={The American Journal of dermatopathology},
  year={2005},
  volume={27 2},
  pages={
          96-101
        }
}
Despite new technologies, few studies have assessed the histologic alterations in patients with melasma. Using current technologies, the present study was designed to re-evaluate the light microscopic, immunohistochemical, and ultrastructural changes of the hyperpigmented and adjacent normal skin of patients with melasma. Twenty-one patients were included in this study. Two millimeter punch biopsies were taken from the hyperpigmented and adjacent normal skin of the face. The integrity of the… CONTINUE READING
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