Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo

@inproceedings{Wang2010LightmediatedAR,
  title={Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo},
  author={Xiaobo Wang and Li He and Yi I. Wu and Klaus Michael Hahn and Denise J Montell},
  booktitle={Nature Cell Biology},
  year={2010}
}
The small GTPase Rac induces actin polymerization, membrane ruffling and focal contact formation in cultured single cells but can either repress or stimulate motility in epithelial cells depending on the conditions. The role of Rac in collective epithelial cell movements in vivo, which are important for both morphogenesis and metastasis, is therefore difficult to predict. Recently, photoactivatable analogues of Rac (PA-Rac) have been developed, allowing rapid and reversible activation or… CONTINUE READING

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