Light-mediated activation reveals a key role for protein kinase A and sarcoma protein kinase in the development of sperm hyper-activated motility.

@article{Shahar2011LightmediatedAR,
  title={Light-mediated activation reveals a key role for protein kinase A and sarcoma protein kinase in the development of sperm hyper-activated motility.},
  author={Shiran Shahar and Amir Wiser and Debby Ickowicz and Rachel Lubart and Adrian Shulman and H Breitbart},
  journal={Human reproduction},
  year={2011},
  volume={26 9},
  pages={2274-82}
}
BACKGROUND Hyper-activated motility (HAM) is part of the sperm capacitation process, which is necessary for fertilization. In this study, we investigated the effect of visible light on sperm motility and hyperactivation and evaluated pathways mediating these effects. METHODS Human sperm (1 × 10⁷ cells/ml) in capacitation media were irradiated for 3 min with 40 mW/cm² visible light (400-800 nm with maximum energy at 600 nm). Sperm motility was assessed and analyzed by computer-assisted sperm… CONTINUE READING
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