Light-inducible activation of target mRNA translation in mammalian cells.

Abstract

A genetically encoded optogenetic system was constructed that activates mRNA translation in mammalian cells in response to light. Blue light induces the reconstitution of an RNA binding domain and a translation initiation domain, thereby activating target mRNA translation downstream of the binding sites.

DOI: 10.1039/c3cc44866e

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@article{Cao2013LightinducibleAO, title={Light-inducible activation of target mRNA translation in mammalian cells.}, author={Jicong Cao and Manish Arha and Chaitanya Sudrik and Lukasz J. Bugaj and David V. Schaffer and Ravi S. Kane}, journal={Chemical communications}, year={2013}, volume={49 75}, pages={8338-40} }