Light induces Fos expression via extracellular signal-regulated kinases 1/2 in melanopsin-expressing PC12 cells.

@article{Moldrup2010LightIF,
  title={Light induces Fos expression via extracellular signal-regulated kinases 1/2 in melanopsin-expressing PC12 cells.},
  author={Marie-Louise Moldrup and Birgitte Georg and Birgitte Falktoft and Rikke N{\o}rmark Mortensen and Jakob Lerche Hansen and Jan Fahrenkrug},
  journal={Journal of neurochemistry},
  year={2010},
  volume={112 3},
  pages={
          797-806
        }
}
The photopigment melanopsin is expressed in a subtype of mammalian ganglion cells in the retina that project to the circadian clock in the hypothalamic suprachiasmatic nucleus to mediate non-visual light information. Melanopsin renders these retinal ganglion cells intrinsically photosensitive and the cells respond to light by a membrane depolarization and induction of the immediate early response gene Fos. Previous studies showed that the light activated melanopsin-induced signaling, the… CONTINUE READING
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