Light-induced reduction of cytoplasmic free calcium in retinal rod outer segment

@article{Yau1985LightinducedRO,
  title={Light-induced reduction of cytoplasmic free calcium in retinal rod outer segment},
  author={K. K. C. Yau and Kei Nakatani},
  journal={Nature},
  year={1985},
  volume={313},
  pages={579-582}
}
The response of retinal rod photoreceptors to light consists of a membrane hyperpolarization resulting from the decrease of a light-sensitive conductance in the outer segment1. According to the calcium hypothesis, this conductance is blocked by a rise in intracellular free Ca triggered by light2, a notion supported by the findings that an induced rise in internal Ca leads to blockage of the light-sensitive conductance3–9 and that light triggers a net Ca efflux from the outer segment via a Na–Ca… CONTINUE READING