Light-induced recruitment of INAD-signaling complexes to detergent-resistant lipid rafts in Drosophila photoreceptors

@article{Sanxaridis2007LightinducedRO,
  title={Light-induced recruitment of INAD-signaling complexes to detergent-resistant lipid rafts in Drosophila photoreceptors},
  author={Parthena D. Sanxaridis and Michelle A. Cronin and Satinder Singh Rawat and Girma Waro and U. M. Acharya and Susan Tsunoda},
  journal={Molecular and Cellular Neuroscience},
  year={2007},
  volume={36},
  pages={36-46}
}
Here, we reveal a novel feature of the dynamic organization of signaling components in Drosophila photoreceptors. We show that the multi-PDZ protein INAD and its target proteins undergo light-induced recruitment to detergent-resistant membrane (DRM) rafts. Reduction of ergosterol, considered to be a key component of lipid rafts in Drosophila, resulted in a loss of INAD-signaling complexes associated with DRM fractions. Genetic analysis demonstrated that translocation of INAD-signaling complexes… CONTINUE READING
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