Light-induced gene expression using messenger RNA molecules.

  title={Light-induced gene expression using messenger RNA molecules.},
  author={Sigurd Leinaes B\oe and Stein Saeb\oe-Larssen and Eivind Hovig},
  volume={20 1},
The exploration of messenger RNA (mRNA) as a potential therapeutic regulator of gene expression has been significantly reduced by the inability of polyplexes to escape the endocytic pathway, combined with the lack of specific targeting. In the present study, we have developed a site-specific delivery strategy for mRNA molecules through the use of photochemical internalization (PCI) technology. When using EGFP mRNA as a model system, a 10- to 40-fold increase in EGFP-positive cells was… CONTINUE READING

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