Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant rhodopsin.

@article{Naash1996LightinducedAO,
  title={Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant rhodopsin.},
  author={M L Naash and Neal S Peachey and Zhao yang Li and C C Gryczan and Yoshinobu Goto and J. Blanks and Ann H. Milam and Harris Ripps},
  journal={Investigative ophthalmology & visual science},
  year={1996},
  volume={37 5},
  pages={775-82}
}
PURPOSE Mutations at various loci on the rhodopsin gene have been shown to cause autosomal dominant retinitis pigmentosa (ADRP). One of the most common is a point mutation (P23H) near the N-terminus of the protein. The authors have studied the effects of light deprivation on the rate of degeneration in pigmented transgenic mice expressing the P23H mutation as well as two additional mutations near the N-terminus of opsin (V20G, P27L). METHODS Transgenic and normal littermates were reared in… CONTINUE READING

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A transgenic mouse model for autosomal dominant retinitis pigmentosa caused by a three base pair deletion in codon 255/256 of the opsin gene. ARVO Abstracts

C Gryczan, JR Kuszak, +3 authors MI. Naash
Invest Ophthalmol Vis Sri • 1995

Apoptosis in retinitis pigmentosa

ZY Li, AH Milam
1995
View 1 Excerpt

Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration.

Proceedings of the National Academy of Sciences of the United States of America • 1995
View 1 Excerpt

Quantitative analysis of mRNA levels of the transgenic and endogenous opsin genes in retinas of transgenic mice. ARVO Abstracts

T Cheng, MI Naash
Invest Ophthalmol Vis Sci. 1995;36:S273 • 1995
View 1 Excerpt

Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.

Proceedings of the National Academy of Sciences of the United States of America • 1994

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