Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina

@article{Stevens2010LightevokedNR,
  title={Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina},
  author={Eric R Stevens and Eric C. Gustafson and Steven J. Sullivan and Manuel Q. Esguerra and Robert F. Miller},
  journal={NeuroReport},
  year={2010},
  volume={21},
  pages={239-244}
}
Experiments were carried out in the retina of the tiger salamander (Ambystoma tigrinum) to evaluate the importance of D-serine synthesis on light-evoked N-methyl D-aspartate (NMDA) receptor-mediated components of ganglion cells and contributions to the proximal negative field potential. We blocked the synthesis of D-serine through brief exposures of the retina to phenazine ethosulfate and validated the changes in the tissue levels of D-serine using capillary electrophoresis methods to separate… 
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Changes in Serine Racemase-Dependent Modulation of NMDA Receptor: Impact on Physiological and Pathological Brain Aging
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  • Biology, Medicine
    Front. Mol. Biosci.
  • 2018
TLDR
This review aims at compelling the most recent experimental evidences indicating that changes in SR-related modulation of NMDARs also govern opposite functional dysfunctions in physiological and pathological (Alzheimer's disease) aging that finally results in memory disabilities in both cases.
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