Light-enhanced and fear-potentiated startle: temporal characteristics and effects of alpha-helical corticotropin-releasing hormone.

@article{Jongh2003LightenhancedAF,
  title={Light-enhanced and fear-potentiated startle: temporal characteristics and effects of alpha-helical corticotropin-releasing hormone.},
  author={Reinoud de Jongh and Lucianne Groenink and Jan van der Gugten and Berend Olivier},
  journal={Biological psychiatry},
  year={2003},
  volume={54 10},
  pages={1041-8}
}
BACKGROUND It has been suggested that the light-enhanced startle paradigm (LES) is an animal model for anxiety, because of the unconditioned and nonspecific cue and the long-term effect. In contrast, the fear-potentiated startle (FPS) is suggested to model fear. In the present study, we assessed in detail the time course of LES and FPS and investigated whether corticotropin-releasing hormone (CRH) is differentially involved in these two models. METHODS In experiment 1, the amplitude of the… CONTINUE READING

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