Light-driven chloride ion transport by halorhodopsin from Natronobacterium pharaonis. 2. Chloride release and uptake, protein conformation change, and thermodynamics.

@article{Varo1995LightdrivenCI,
  title={Light-driven chloride ion transport by halorhodopsin from Natronobacterium pharaonis. 2. Chloride release and uptake, protein conformation change, and thermodynamics.},
  author={G. Varo and Richard Needleman and Janos K. Lanyi},
  journal={Biochemistry},
  year={1995},
  volume={34 44},
  pages={14500-7}
}
The photocycle of the light-driven chloride pump, N. pharaonis halorhodopsin, is described by the scheme HR-->K--><==>L<==>N<==>O<==>HR'-->HR. From the chloride dependencies of the rate constants in this model we identify the N-->O and O-->HR' reactions as the steps where chloride release and uptake occur, respectively, during the transport. The dependencies of the rate constants on temperature describe a thermodynamic cycle in which enthalpy-entropy conversion occurs in the O-->HR' reaction… CONTINUE READING

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