Light-driven DNA repair by photolyases

  title={Light-driven DNA repair by photolyases},
  author={Lars Oliver Essen and Tobias Klar},
  journal={Cellular and Molecular Life Sciences CMLS},
DNA photolyases are highly efficient light-driven DNA repair enzymes which revert the genomedamaging effects caused by ultraviolet (UV) radiation. These enzymes occur in almost all living organisms exposed to sunlight, the only exception being placental mammals like humans and mice. Their catalytic mechanism employs the light-driven injection of an electron onto the DNA lesion to trigger the cleavage of cyclobutane- pyrimidine dimers or 6-4 photoproducts inside duplex DNA. Spectroscopic and… CONTINUE READING
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