Light-directed, spatially addressable parallel chemical synthesis.

  title={Light-directed, spatially addressable parallel chemical synthesis.},
  author={Stephen P. A. Fodor and John L. Read and Michael C. Pirrung and Lubert Stryer and Amy Tsai Lu and Dennis W. Solas},
  volume={251 4995},
Solid-phase chemistry, photolabile protecting groups, and photolithography have been combined to achieve light-directed, spatially addressable parallel chemical synthesis to yield a highly diverse set of chemical products. Binary masking, one of many possible combinatorial synthesis strategies, yields 2n compounds in n chemical steps. An array of 1024 peptides was synthesized in ten steps, and its interaction with a monoclonal antibody was assayed by epifluorescence microscopy. High-density… CONTINUE READING
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