Light-dependent sequestration of TIMELESS by CRYPTOCHROME.

  title={Light-dependent sequestration of TIMELESS by CRYPTOCHROME.},
  author={M Fernanda Ceriani and T K Darlington and David Staknis and Paloma Mas and Allegra Petti and Charles J. Weitz and Steve A Kay},
  volume={285 5427},
Most organisms have circadian clocks consisting of negative feedback loops of gene regulation that facilitate adaptation to cycles of light and darkness. In this study, CRYPTOCHROME (CRY), a protein involved in circadian photoperception in Drosophila, is shown to block the function of PERIOD/TIMELESS (PER/TIM) heterodimeric complexes in a light-dependent fashion. TIM degradation does not occur under these conditions; thus, TIM degradation is uncoupled from abrogation of its function by light… CONTINUE READING
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