Light and electron microscopic in-situ hybridization of collagen type I and type II mRNA in the fibrocartilaginous tissue of late-stage osteoarthritis.

@article{Miosge1998LightAE,
  title={Light and electron microscopic in-situ hybridization of collagen type I and type II mRNA in the fibrocartilaginous tissue of late-stage osteoarthritis.},
  author={Nicolai Miosge and K Waletzko and Christa Bode and Fabio Quondamatteo and Will Schultz and Rainer Herken},
  journal={Osteoarthritis and cartilage},
  year={1998},
  volume={6 4},
  pages={278-85}
}
OBJECTIVE Biochemical analysis indicates the presence of collagen type I in fibrocartilaginous tissue of osteoarthritic cartilage, whereas normal hyaline cartilage contains only collagen type II produced by normal chondrocytes. Fibrocartilaginous tissue of late-stage osteoarthritis also exhibits irregularly shaped type 2b secretory chondrocytes as described in the literature. We have attempted to elucidate the type of cell which produces each type of collagen in late-stage osteoarthritis… CONTINUE READING

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