Corpus ID: 14762740

Light and Electron Microscopic Study on the Effect of Aspartame on the Cerebellar Cortex of Male Albino Rat

  title={Light and Electron Microscopic Study on the Effect of Aspartame on the Cerebellar Cortex of Male Albino Rat},
  author={Abeer A. Abd El-Samad},
Introduction: Aspartame (ASP) is the most widely used artificial sweeteners entering in the component of many foods and beverages. There was a great matter of controversy about the effect of aspartame on body cells. Aim of the Work: Was to evaluate the effect of aspartame on the structure the cerebellar cortex in rats. Materials and Methods: Fifteen male adult albino rats were used. The animals were divided into three groups, each containing five rats. Group I served as control. Group II… Expand
Background: Aspartame is considered the most widely used nocaloric artificial sweetener. It is used in a variety of food products and beverages. However, the consumption of aspartame has beenExpand
Effect of long term-administration of aspartame on the ultrastructure of sciatic nerve
  • E. Okasha
  • Chemistry, Medicine
  • Journal of microscopy and ultrastructure
  • 2016
It was concluded that long-term administration of aspartame had a harmful effect on the structure of sciatic nerve and 1 month stoppage of as partame was not enough to achieve complete recovery. Expand
Does curcumin protect against hazards of aspartame intake on the cerebellar cortex of male adult albino rats? Histological and immunohistochemical study
  • I. Ibrahim
  • Medicine
  • Journal of Medical Histology
  • 2019
Cerebellar cortex of aspartametreated group showed features of neurodegeneration of purkinje cells with areas of neuropil loss in the molecular and granular layers, so supplementation of curcuminin diet is recommended with regular intake of as partame. Expand
Difference between natural and artificial sweeteners: Histopathological studies on male albino rat’s brain (hippocampus)
The present work is a trial to compare effect of short and long term administrations of sucrose as a natural widely used sweetener, aspartame as a synthetic non-caloric sweetener and stevia as aExpand
Ameliorative Effect of Pimpinella anisum Oil on Immunohistochemical and Ultrastuctural Changes of Cerebellum of Albino Rats Induced by Aspartame
The histopathological, immunohistochemical and ultrastructural alterations were much less observed in concomitant use of P. anisum oil with ASP than in controls, indicating a protective action against neurotoxicity. Expand
The possible neuroprotective effect of astaxanthin on monosodium glutamate and aspartame induced hippocampal changes in albino rats: (Histological and immuno-histochemical study)
Abstract:Background: Food additives are substances added to food to improve its safety, freshness, taste, texture, or appearance. They include aroma enhancer eg : monosodium glutamate(MSG) orExpand
Methyl aspartylphenylalanine, the pons and cerebellum in mice: An evaluation of motor, morphological, biochemical, immunohistochemical and apoptotic effects
It was concluded that repeated oral administration of the higher doses of aspartame was associated with morphological alterations suggestive of neuronal injury, and derangement of antioxidant status. Expand
A comparative study of the effect of diet and soda carbonated drinks on the histology of the cerebellum of adult female albino Wistar rats.
The results suggest that diet soda has adverse effect on the cerebellum of adult female albino Wistar rats, with shrunken and degenerated Purkinje cells with hypertrophied dendrites. Expand
The Effect of Diet Coke and Monosodium Glutamate on the Cerebellar Cortex of Adult Male Albino Rats. Histological and Immuno-histochemical Study
Histological examination of the cerebellar cortex revealed that both Diet Coke and MSG either separately or in combination resulted in degenerative changes that were more significant in the combination group. Expand
Alterations in behaviour, cerebral cortical morphology and cerebral oxidative stress markers following aspartame ingestion
The study showed morphological alterations consistent with neuronal injury and biochemical changes of oxidative stress following repeated administration of aspartame, which supports the need for caution in the indiscriminate use of as partame as a non-nutritive sweetener. Expand


The effect of aspartame on acetylcholinesterase activity in hippocampal homogenates of suckling rats.
Low concentrations of ASP components had no effect on hippocampal and pure AChE activity, whereas high or toxic concentrations remarkably decreased both enzyme activities. Expand
First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats
APM is a multipotential carcinogenic agent, even at a daily dose of 20 mg/kg body weight, much less than the current acceptable daily intake, and a reevaluation of the present guidelines on the use and consumption of APM is urgent and cannot be delayed. Expand
Neurobiochemical alterations induced by the artificial sweetener aspartame (NutraSweet).
Findings are consistent with ASM-induced increases in the brain catecholamine precursor amino acids phenylalanine and tyrosine, as reported earlier, and may be responsible for the reported clinical and behavioral effects associated with AsM ingestion. Expand
Direct and indirect cellular effects of aspartame on the brain
It is proposed that excessive aspartame ingestion might be involved in the pathogenesis of certain mental disorders (DSM-IV-TR 2000) and also in compromised learning and emotional functioning. Expand
High doses of aspartame have no effects on sensorimotor function or learning and memory in rats.
Under the conditions of these experiments, large doses of aspartame have no significant neurobiological effects in adult rats as measured by procedures known to be sensitive to the neurobiologically effects of neurotoxicants, including convulsants, organochlorine insecticides and heavy metals. Expand
The Effect of Aspartame on Rat Brain Xenobiotic-Metabolizing Enzymes
It is demonstrated that chronic aspartame (ASP) consumption leads to an increase of phase I metabolizing enzymes (cytochrome P450 (CYP)) in rat brain and the pattern of induction of CYP immunoreactive proteins by ASP paralleled that of 4-NHP, PROD, BROD, END, EROD- and MROD-related activities only in the cerebellum. Expand
Formaldehyde derived from dietary aspartame binds to tissue components in vivo.
It is concluded that aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts. Expand
Aspartame: neuropsychologic and neurophysiologic evaluation of acute and chronic effects.
Large daily doses of aspartame had no effect on neuropsychologic, neurophysiologic, or behavioral functioning in healthy young adults. Expand
Chronic aspartame affects T-maze performance, brain cholinergic receptors and Na+,K+-ATPase in rats
It can be concluded from data that long-term consumption of aspartame can affect T-maze performance in rats and alter receptor densities or enzymes in brain. Expand
Aspartame: A Safety Evaluation Based on Current Use Levels, Regulations, and Toxicological and Epidemiological Studies
The data from the extensive investigations into the possibility of neurotoxic effects of aspartame, in general, do not support the hypothesis that aspartam in the human diet will affect nervous system function, learning or behavior. Expand