• Corpus ID: 14762740

Light and Electron Microscopic Study on the Effect of Aspartame on the Cerebellar Cortex of Male Albino Rat

  title={Light and Electron Microscopic Study on the Effect of Aspartame on the Cerebellar Cortex of Male Albino Rat},
  author={Abeer A. Abd El-Samad},
Introduction: Aspartame (ASP) is the most widely used artificial sweeteners entering in the component of many foods and beverages. There was a great matter of controversy about the effect of aspartame on body cells. Aim of the Work: Was to evaluate the effect of aspartame on the structure the cerebellar cortex in rats. Materials and Methods: Fifteen male adult albino rats were used. The animals were divided into three groups, each containing five rats. Group I served as control. Group II… 
Background: Aspartame is considered the most widely used nocaloric artificial sweetener. It is used in a variety of food products and beverages. However, the consumption of aspartame has been
Effect of long term-administration of aspartame on the ultrastructure of sciatic nerve
  • E. Okasha
  • Chemistry, Medicine
    Journal of microscopy and ultrastructure
  • 2016
It was concluded that long-term administration of aspartame had a harmful effect on the structure of sciatic nerve and 1 month stoppage of as partame was not enough to achieve complete recovery.
Does curcumin protect against hazards of aspartame intake on the cerebellar cortex of male adult albino rats? Histological and immunohistochemical study
  • I. Ibrahim
  • Medicine
    Journal of Medical Histology
  • 2019
Cerebellar cortex of aspartametreated group showed features of neurodegeneration of purkinje cells with areas of neuropil loss in the molecular and granular layers, so supplementation of curcuminin diet is recommended with regular intake of as partame.
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A comparative study of the effect of diet and soda carbonated drinks on the histology of the cerebellum of adult female albino Wistar rats.
The results suggest that diet soda has adverse effect on the cerebellum of adult female albino Wistar rats, with shrunken and degenerated Purkinje cells with hypertrophied dendrites.
The Effect of Diet Coke and Monosodium Glutamate on the Cerebellar Cortex of Adult Male Albino Rats. Histological and Immuno-histochemical Study
Histological examination of the cerebellar cortex revealed that both Diet Coke and MSG either separately or in combination resulted in degenerative changes that were more significant in the combination group.
Alterations in behaviour, cerebral cortical morphology and cerebral oxidative stress markers following aspartame ingestion
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Low concentrations of ASP components had no effect on hippocampal and pure AChE activity, whereas high or toxic concentrations remarkably decreased both enzyme activities.
First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats
APM is a multipotential carcinogenic agent, even at a daily dose of 20 mg/kg body weight, much less than the current acceptable daily intake, and a reevaluation of the present guidelines on the use and consumption of APM is urgent and cannot be delayed.
Neurobiochemical alterations induced by the artificial sweetener aspartame (NutraSweet).
Findings are consistent with ASM-induced increases in the brain catecholamine precursor amino acids phenylalanine and tyrosine, as reported earlier, and may be responsible for the reported clinical and behavioral effects associated with AsM ingestion.
Direct and indirect cellular effects of aspartame on the brain
It is proposed that excessive aspartame ingestion might be involved in the pathogenesis of certain mental disorders (DSM-IV-TR 2000) and also in compromised learning and emotional functioning.
High doses of aspartame have no effects on sensorimotor function or learning and memory in rats.
Under the conditions of these experiments, large doses of aspartame have no significant neurobiological effects in adult rats as measured by procedures known to be sensitive to the neurobiologically effects of neurotoxicants, including convulsants, organochlorine insecticides and heavy metals.
The Effect of Aspartame on Rat Brain Xenobiotic-Metabolizing Enzymes
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Formaldehyde derived from dietary aspartame binds to tissue components in vivo.
It is concluded that aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts.
Aspartame: neuropsychologic and neurophysiologic evaluation of acute and chronic effects.
Large daily doses of aspartame had no effect on neuropsychologic, neurophysiologic, or behavioral functioning in healthy young adults.
Chronic aspartame affects T-maze performance, brain cholinergic receptors and Na+,K+-ATPase in rats
It can be concluded from data that long-term consumption of aspartame can affect T-maze performance in rats and alter receptor densities or enzymes in brain.
Aspartame: A Safety Evaluation Based on Current Use Levels, Regulations, and Toxicological and Epidemiological Studies
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