Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies.

@article{Osborne2008LightAM,
  title={Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies.},
  author={Neville N. Osborne and Guang-Yu Li and Dan Ji and Heather Jane Mortiboys and Sandra J. Jackson},
  journal={Journal of neurochemistry},
  year={2008},
  volume={105 5},
  pages={2013-28}
}
Retinal ganglion cell axons within the globe are laden with mitochondria that are unprotected from light (400-760 nm) impinging onto the retina. Light can be absorbed by mitochondrial enzymes such as cytochrome and flavin oxidases causing the generation of reactive oxygen species, and we have suggested this may pose a risk to ganglion cell survival if their energy state is compromised, as may be so in glaucoma or in Leber's Hereditary Optic Neuropathy. Here, we demonstrate that light (400-760… CONTINUE READING