Light-activated ion channels for remote control of neuronal firing

@article{Banghart2004LightactivatedIC,
  title={Light-activated ion channels for remote control of neuronal firing},
  author={Matthew R. Banghart and Katharine Borges and Ehud Y Isacoff and Dirk Trauner and Richard H. Kramer},
  journal={Nature Neuroscience},
  year={2004},
  volume={7},
  pages={1381-1386}
}
Neurons have ion channels that are directly gated by voltage, ligands and temperature but not by light. Using structure-based design, we have developed a new chemical gate that confers light sensitivity to an ion channel. The gate includes a functional group for selective conjugation to an engineered K+ channel, a pore blocker and a photoisomerizable azobenzene. Long-wavelength light drives the azobenzene moiety into its extended trans configuration, allowing the blocker to reach the pore… Expand
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