Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1.

@article{Belmonte2006LightInducedPD,
  title={Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1.},
  author={M{\^o}nica Aparecida Belmonte and Marinilce Fagundes dos Santos and Alexandre Hiroaki Kihara and Chao Yun Irene Yan and D{\^a}nia Emi Hamassaki},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 3},
  pages={1193-200}
}
PURPOSE Rho GTPases play a central role in actin-based cytoskeleton reorganization, and they participate in signaling pathways that regulate gene transcription, cell cycle entry, and cell survival. This study verifies the role of Rac1 during light-induced retinal degeneration. METHODS BALB/c mice were exposed to degenerative light stimulus, and their eyes were enucleated immediately or after the mice were kept in the dark for 6, 24, and 48 hours. Retinas were fixed and processed for… CONTINUE READING

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