Light Chain Usage in Anti–double-stranded DNA B Cell Subsets: Role in Cell Fate Determination

@article{Spatz1997LightCU,
  title={Light Chain Usage in Anti–double-stranded DNA B Cell Subsets: Role in Cell Fate Determination},
  author={Linda A. Spatz and Vladimir Saenko and Andrey Iliev and Lori Jones and Larisa J. Geskin and Betty Diamond},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={185},
  pages={1317 - 1326}
}
Two major mechanisms for the regulation of autoreactive B cells that arise in the bone marrow are functional silencing (anergy) and deletion. Studies to date suggest that low avidity interactions between B cells and autoantigen lead to B cell silencing, whereas high avidity interactions lead to deletion. Anti-double stranded (ds) DNA antibodies represent a pathogenic autospecificity in Systemic Lupus Erythematosus (SLE). An understanding of their regulation is critical to an understanding of… CONTINUE READING

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