Light Activation of Channelrhodopsin-2 in Excitable Cells of Caenorhabditis elegans Triggers Rapid Behavioral Responses

@article{Nagel2005LightAO,
  title={Light Activation of Channelrhodopsin-2 in Excitable Cells of Caenorhabditis elegans Triggers Rapid Behavioral Responses},
  author={Georg Nagel and Martin Brauner and Jana F Liewald and Nona Adeishvili and Ernst Bamberg and Alexander Gottschalk},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={2279-2284}
}
For studying the function of specific neurons in their native circuitry, it is desired to precisely control their activity. This often requires dissection to allow accurate electrical stimulation or neurotransmitter application , and it is thus inherently difficult in live animals, especially in small model organisms. Here, we employed channelrhodopsin-2 (ChR2), a directly light-gated cation channel from the green alga Chlamydomonas reinhardtii, in excitable cells of the nematode Caenorhabditis… Expand
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