Ligation of the lymphocyte homing receptor CD44 triggers T-helper and cytolytic functions of human T cells

@article{Galandrini1993LigationOT,
  title={Ligation of the lymphocyte homing receptor CD44 triggers T-helper and cytolytic functions of human T cells},
  author={Ricciarda Galandrini and Rita Tognellini and Nicola Albi and Anna Vecchiarelli and Daniela Zarcone and Carlo Enrico Grossi and Andrea Velardi},
  journal={Cytotechnology},
  year={1993},
  volume={11},
  pages={S100-S102}
}
We show that antibodies to the CD44 molecule trigger proliferation of human CD3+/CD4+ T-cell clones. Such effect is IL2-dependent, as shown by IL2 production induced by anti-CD44 mAb and by inhibition of cell proliferation in the presence of anti-IL2 antibodies or cyclosporin A (CsA). Moreover, anti-CD44 mAb triggered human cytolytic CD4+ and CD8+ TCR α/β+ clones, and Vδ1 or Vδ2 TCR Y/δ+ clones to lyse Fc-gamma-R+ P815 cells and to release granule trypsin-like esterase enzymes. Anti-CD44 mAb… CONTINUE READING