Ligation of the CD44 adhesion molecule inhibits drug-induced apoptosis in human myeloid leukemia cells.

@article{Allouche2000LigationOT,
  title={Ligation of the CD44 adhesion molecule inhibits drug-induced apoptosis in human myeloid leukemia cells.},
  author={Mich{\`e}le Allouche and Rachida Sihem Charrad and Ali Bettaieb and Catherine Greenland and C{\'e}cile Grignon and F Smadja-joffe},
  journal={Blood},
  year={2000},
  volume={96 3},
  pages={1187-90}
}
Adhesion molecules can improve hematopoietic cell survival; however, their role in leukemic cell resistance to drug-induced apoptosis is poorly documented. The CD44 adhesion molecule is strongly expressed on acute myeloid leukemia (AML) blasts. Using 2 myeloid cell lines, HL60 and NB4, evidence is presented that prior incubation with the CD44-specific monoclonal antibody (mAb) A3D8, reported to induce differentiation of AML blasts, significantly decreases apoptosis induced by 3 drugs used in… CONTINUE READING

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