Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling.

@article{Colgan1999LigationOI,
  title={Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling.},
  author={Sean P Colgan and Robert M. Hershberg and Glenn T Furuta and Richard S Blumberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 24},
  pages={13938-43}
}
The intestinal epithelium is anatomically positioned to serve as the critical interface between the lumen and the mucosal immune system. In addition to MHC class I and II antigens, intestinal epithelia constitutively express the nonclassical MHC molecule CD1d, a transmembrane molecule with a short cytoplasmic tail expressed as a beta(2)-microglobulin-associated 48-kDa glycoprotein and novel beta(2)-microglobulin-independent 37-kDa nonglycosylated protein on intestinal epithelia. At present, it… CONTINUE READING

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