Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes.

@article{Steeber1997LigationOL,
  title={Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes.},
  author={Douglas A. Steeber and Pablo Engel and Ann S. Miller and Michael P Sheetz and Thomas F. Tedder},
  journal={Journal of immunology},
  year={1997},
  volume={159 2},
  pages={952-63}
}
L-selectin is a cell surface adhesion receptor that mediates leukocyte rolling along vascular endothelium at sites of inflammation and lymphocyte attachment to endothelial cells within peripheral lymphoid tissues. Since ligation of L-selectin through its ligand recognition region may mimic physiologic ligand binding, a new panel of mAbs that engaged a conserved ligand-binding region within the lectin domains of human, mouse, and rat L-selectin were generated using L-selectin-deficient mice… CONTINUE READING