Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-κB pathway in BMP-2 expression.

@article{Wang2014LigationOI,
  title={Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-κB pathway in BMP-2 expression.},
  author={Dong Wang and Qingchun Zeng and Rui Song and Lihua Ao and David Fullerton and Xianzhong Meng},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1843 11},
  pages={2744-53}
}
Calcific aortic valve disease (CAVD) is a chronic inflammatory condition and affects a large number of elderly people. Aortic valve interstitial cells (AVICs) occupy an important role in valvular calcification and CAVD progression. While pro-inflammatory mechanisms are capable of inducing the osteogenic responses in AVICs, the molecular interaction between pro-inflammatory and pro-osteogenic mechanisms remains poorly understood. This study tested the hypothesis that intercellular adhesion… CONTINUE READING

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