Ligation of CD23 triggers cyclic AMP generation in human B lymphocytes.

  title={Ligation of CD23 triggers cyclic AMP generation in human B lymphocytes.},
  author={J. P. Kolb and A. 5836 Abadie and N. Paul-Eugene and Monique Capron and Marika Sarfati and Bernard Dugas and Guy J. Delespesse},
  journal={Journal of immunology},
  volume={150 11},
The low affinity IgE receptor CD23 may play a role in several B lymphocyte functions, such as cell activation and multiplication, Ag presentation, and IgE production. We have previously reported that ligation of the CD23 molecule with anti-CD23 mAb, or IgE-anti-IgE complexes, leads to phosphoinositide hydrolysis and calcium mobilization through the generation of Inositol (1,4,5) trisphosphate via a process involving a Pertussis toxin insensitive GTP-binding protein. In our work, we show that… CONTINUE READING

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