Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism

@article{Medina2009LigandsOT,
  title={Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism},
  author={Philippe de Medina and B Payre and Nadia Boubekeur and Justine Bertrand-Michel and François Terc{\'e} and Sandrine Silvente-Poirot and Marc Poirot},
  journal={Cell Death and Differentiation},
  year={2009},
  volume={16},
  pages={1372-1384}
}
We have recently reported that cytostatic concentrations of the microsomal antiestrogen-binding site (AEBS) ligands, such as PBPE (N-pyrrolidino-(phenylmethyphenoxy)-ethanamine,HCl) and tamoxifen, induced differentiation characteristics in breast cancer cells through the accumulation of post-lanosterol intermediates of cholesterol biosynthesis. We show here that exposure of MCF-7 (human breast adenocarcinoma cell line) cells to higher concentrations of AEBS ligands triggered active cell death… CONTINUE READING

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