Ligands for the T-cell receptor: hard times for avidity models.

Abstract

T-cell activation occurs when the T-cell receptor (TCR) binds to a self major histocompatibility complex (MHC) molecule carrying a specific peptide. Small changes in peptide structure can alter or inhibit this response. Although this phenomenon is normally attributed to a lowering of the avidity of the ligand for its receptor, recent data suggest that… (More)

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