Ligands for the Nuclear Peroxisome Proliferator-Activated Receptor Gamma.

@article{Sauer2015LigandsFT,
  title={Ligands for the Nuclear Peroxisome Proliferator-Activated Receptor Gamma.},
  author={Sascha Sauer},
  journal={Trends in pharmacological sciences},
  year={2015},
  volume={36 10},
  pages={688-704}
}
Nuclear receptors are ligand-activated transcription factors, which represent a primary class of drug targets. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is a key player in various biological processes. PPARγ is widely known as the target protein of the thiazolidinediones for treating type 2 diabetes. Moreover, PPARγ ligands can induce anti-inflammatory and potentially additional beneficial effects. Recent mechanistic insights of PPARγ modulation give hope the… CONTINUE READING