Ligands for in vivo imaging of nicotinic receptor subtypes in Alzheimer brain

@article{Sihver2000LigandsFI,
  title={Ligands for in vivo imaging of nicotinic receptor subtypes in Alzheimer brain},
  author={Wiebke Sihver and Bengt L{\aa}ngstr{\"o}m and Agneta Nordberg},
  journal={Acta Neurologica Scandinavica},
  year={2000},
  volume={102}
}
The neuronal nicotinic acetylcholine receptors (nAChR) are involved in functional processes in brain including cognitive function and memory. A severe loss of the nAChRs has been detected in brain of patients with Alzheimer's disease (AD). There is a great interest to image nAChRs noninvasive for detection of receptor impairments even at a presymptomatic stage of AD as well for monitoring outcome of drug treatment. (S) [11C]Nicotine, has so far been the only nAChR ligand used in positron… 
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