Ligands for antibody to M-protein are exposed at the surface of influenza virions: effect of proteolytic treatment on their activity.

@article{Reginster1979LigandsFA,
  title={Ligands for antibody to M-protein are exposed at the surface of influenza virions: effect of proteolytic treatment on their activity.},
  author={Monique Reginster and L. Joassin and P Fontaine-Delcambe},
  journal={The Journal of general virology},
  year={1979},
  volume={45 2},
  pages={283-9}
}
Antiserum to pure M-protein extracted from PR8 virions neutralized the infectivity and inhibited the haemagglutinating activity of various influenza A virions. It agglutinated concentrated suspensions of these virions and fixed complement in their presence. Antibodies to M-protein were readily absorbed by intact virions or by spikeless particles obtained after proteolytic treatment, giving clear evidence that M-protein is exposed at the surface of the virus envelope. The data suggest that when… CONTINUE READING