Ligands for ErbB-family receptors encoded by a neuregulin-like gene

@article{Chang1997LigandsFE,
  title={Ligands for ErbB-family receptors encoded by a neuregulin-like gene},
  author={Han Soo Chang and David J. Riese and Walter Gilbert and David F. Stern and Uel Jackson McMahan},
  journal={Nature},
  year={1997},
  volume={387},
  pages={509-512}
}
Neuregulins (also called ARIA1, GGF2, heregulin3 or NDF4) are a group of polypeptide factors that arise from alternative RNA splicing of a single gene. Through their interaction with the ErbB family of receptors (ErbB2, ErbB3 and ErbB4), neuregulins help to regulate cell growth and differentiation in many tissues5–7. Here we report the cloning of a second neuregulin-like gene, neuregulin-2. The encoded product of the neuregulin-2 gene has a motif structure similar to that of neuregulins and an… 
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TLDR
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Differential Signaling by the Epidermal Growth Factor-like Growth Factors Neuregulin-1 and Neuregulin-2*
TLDR
The neuregulins comprise a subfamily of epidermal growth factor (EGF)-like growth factors that elicit diverse cellular responses by activating members of the ErbB family of receptor tyrosine kinases and results imply that EGF-like ligands might elicit differential signaling within the context of a single receptor heterodimer.
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