Ligands differentially modify the nuclear mobility of estrogen receptors alpha and beta.

@article{Damdimopoulos2008LigandsDM,
  title={Ligands differentially modify the nuclear mobility of estrogen receptors alpha and beta.},
  author={Anastasios E. Damdimopoulos and Giannis Spyrou and Jan-{\AA}ke Gustafsson},
  journal={Endocrinology},
  year={2008},
  volume={149 1},
  pages={339-45}
}
Signaling of nuclear receptors depends on the structure of their ligands, with different ligands eliciting different responses. In this study using a comparative analysis, an array of ligands was examined for effects on estrogen receptor alpha (ERalpha) and ERbeta mobility. Our results indicated that these two receptors share similarities in response to some ligands but differ significantly in response to others. Our results suggest that for ERalpha, ligands can be classified into three… CONTINUE READING

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