Ligandin, the glutathione S-transferases, and chemically induced hepatocarcinogenesis: a review.

@article{Smith1977LigandinTG,
  title={Ligandin, the glutathione S-transferases, and chemically induced hepatocarcinogenesis: a review.},
  author={G. Jason Smith and V S Ohl and Gerald Litwack},
  journal={Cancer research},
  year={1977},
  volume={37 1},
  pages={8-14}
}
The glutathione S-transferases are a major group of soluble liver proteins that are involved in the cellular detoxification of electrophilic compounds. Several of these transferases, in particular glutathione S-transferase B or ligandin, interact with chemical carcinogens in vivo. This review presents evidence that ligandin and the other glutathione S-transferases reduce the susceptibility of the liver to aminoazo dye-, polycyclic aromatic hydrocarbon-, and aromatic amine-induced carcinogenesis… CONTINUE READING