Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines.

@article{Yoon2000LigandSD,
  title={Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines.},
  author={Kyungsil Yoon and L Pellaroni and Kavita Ramamoorthy and Kevin W Gaido and Stephen Safe},
  journal={Molecular and cellular endocrinology},
  year={2000},
  volume={162 1-2},
  pages={211-20}
}
Differences in ligand-activation of estrogen receptor alpha (ER(alpha)) were investigated in human HepG2 liver carcinoma and U2 osteogenic sarcoma cells transfected with wild-type ER (ER-wt) and variants expressing only activation function 1 (ERAF1) or AF2 (ER-AF2). The estrogen-responsive C3-luc construct containing the complement C3 gene promoter linked to a bacterial luciferase reporter gene was used to determine ligand-induced wild-type or variant ER activation. The quality pattern of ER… CONTINUE READING

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