Ligand specificity of odorant receptors.

@article{Khafizov2007LigandSO,
  title={Ligand specificity of odorant receptors.},
  author={Kamil Khafizov and Claudio Anselmi and Anna Menini and Paolo Carloni},
  journal={Journal of molecular modeling},
  year={2007},
  volume={13 3},
  pages={401-9}
}
Odorant receptors belong to class A of the G protein-coupled receptors (GPCRs) and detect a large number of structurally diverse odorant molecules. A recent structural bioinformatic analysis suggests that structural features are conserved across class A of GPCRs in spite of their low sequence identity. Based on this work, we have aligned the sequences of 29 ORs for which ligand binding data are available. Recent site-directed mutagenesis experiments on one such receptor (MOR174-9) provide… CONTINUE READING

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