Ligand specificity and evolution of liver X receptors.

  title={Ligand specificity and evolution of liver X receptors.},
  author={Erica J. Reschly and Ni Ai and William J. Welsh and Sean Ekins and Lee R. Hagey and Matthew D. Krasowski},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={110 1-2},
Liver X receptors (LXRs) are key regulators of lipid and cholesterol metabolism in mammals. Little is known, however, about the function and evolution of LXRs in non-mammalian species. The present study reports the cloning of LXRs from African clawed frog (Xenopus laevis), Western clawed frog (Xenopus tropicalis), and zebrafish (Danio rerio), and their functional characterization and comparison with human and mouse LXRs. Additionally, an ortholog of LXR in the chordate invertebrate Ciona… CONTINUE READING