Ligand specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1

@inproceedings{FloresOtero2014LigandSE,
  title={Ligand specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1},
  author={Jacqueline Flores-Otero and Kwang H. Ahn and Francheska Delgado-Peraza and Ken Mackie and Debra A. Kendall and Guillermo Ariel Yudowski},
  booktitle={Nature communications},
  year={2014}
}
G protein-coupled receptors (GPCRs) are the major transducers of external stimuli and key therapeutic targets in many pathological conditions. When activated by different ligands, one receptor can elicit multiple signalling cascades that are mediated by G proteins or β-arrestin, a process defined as functional selectivity or ligand bias. However, the dynamic mechanisms underlying β-arrestin signalling remain unknown. Here by studying the cannabinoid receptor 1 (CB1R), we identify ligand… CONTINUE READING
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