Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction.

@article{Ronacher2009LigandselectiveTA,
  title={Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction.},
  author={Katharina Ronacher and Katie E Hadley and Chanel Avenant and Elisabeth Stubsrud and S. Stoney Simons and Ann Louw and Janet P Hapgood},
  journal={Molecular and cellular endocrinology},
  year={2009},
  volume={299 2},
  pages={219-31}
}
The mechanisms that determine ligand-selective transcriptional responses by the glucocorticoid receptor (GR) are not fully understood. Using a wide panel of GR ligands, we investigated the relationships between the potency and maximal response for transactivation via a glucocorticoid response element (GRE) and transrepression via both nuclear factor small ka, CyrillicB (NFsmall ka, CyrillicB) and activator protein-1 (AP-1) sites, relative binding affinity for the GR, as well as interaction with… CONTINUE READING

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