Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics.

@article{Solt2010LigandRO,
  title={Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics.},
  author={Laura A Solt and Patrick R. Griffin and Thomas P Burris},
  journal={Current opinion in lipidology},
  year={2010},
  volume={21 3},
  pages={204-11}
}
PURPOSE OF REVIEW In the late 1980s, the cloning of several nuclear receptors led to the intense search and isolation of new members of this superfamily. Despite their identification, many of these receptors were dubbed 'orphan' receptors, as their physiological ligands remained unknown. Recent reports have presented evidence for one family of orphan receptors, the retinoic acid receptor-related orphan receptors (RORs), in several pathologies, including osteoporosis, several autoimmune diseases… CONTINUE READING
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