Ligand of scavenger receptor class A indirectly induces maturation of human blood dendritic cells via production of tumor necrosis factor-alpha.

@article{Jin2009LigandOS,
  title={Ligand of scavenger receptor class A indirectly induces maturation of human blood dendritic cells via production of tumor necrosis factor-alpha.},
  author={Jun-O Jin and Hae-Young Lopilly Park and Qi Xu and Joo-In Park and Tatyana Zvyagintseva and Valentin A Stonik and Jong-Young Kwak},
  journal={Blood},
  year={2009},
  volume={113 23},
  pages={5839-47}
}
Dendritic cells (DCs) are the most potent antigen-presenting cells for naive T cells. In this study, scavenger receptor class A type I and type II (SR-A) were shown to be expressed by peripheral blood DCs (PBDCs) and monocyte-derived DCs (MDDCs). In addition, the binding of anti-SR-A antibody to these cells was lower in the presence of fucoidan, an SR-A agonist. Treatment of these DCs with fucoidan or anti-SR-A antibody markedly increased the surface expression of costimulatory molecules CD83… CONTINUE READING
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